Nephrisol Nephrisol
Product
Product Nephrisol
Product

jl=.vq wld¾hlaIu;djh iy mQ¾j vh,isia wjia:dfõ miqjk frda.Ska yg ksoka.; jl=.vq frda. we;s ùu wju lsÍu i|ydu iqúfYaIfhkau ilia lrk ,o uqLdOdrfhka iy k, wdOdrfhka jqjo Ndú; l, yels fmdaIK w;sf¾lhla f,i —fk*aßfida,a˜ yªkajd Èh yel

—fk*aßfida,a˜ ys wvx.= fmdaIH mod¾: (

  • wju fm%daàk w.hka
  • w;HdjYH weuhsfkda wï, 09 lska iïmq¾K lr we;’ ^by< ÔjúoHd;aul jákslula we;s fm%daàk &
  • úgñka j¾. 11 lska iy Lksc mod¾:hka 07 lska iïmQ¾K ù we;
  • ,elafgdia rys;h

Brands Info

Feature Benefit

úfYaI ,laIKh m%;s,dN
ksoka.; jl=.vq frda. i`oydu úfYaIfhkau ilia lrk ,o ixfhda.hls ffoksl fmdaIK wjYH;d iemsrSu muKlau fkdj frda.Skaf.a  ffjoH ;;ajhka i|ydo jvd;a fhda.H fõ
wju fm%daàk w.h mQ¾j vh,isia wjia:dfõ§ jl=.vq foflys l%shdldÍ;ajh ksisf,i mj;ajd .ekSu
 ksoka.; jl=.vq frda.h fjkqfjkau ilia lrk ,o Lksc j¾. kqiqÿiq laIqø fmdaIl fldgia Ndú;fhka we;súh yels Nhdkl m%;sM, j<lajhs
ldfndayhsfâ%g m%Njh f,i fuda,afgdafvlaiaá%ka myiqfjka Èh fjk iq¨ nj iy wjfYdaIKh ^WKq c,h fkdjk& fõ’ fïofha yd fm%daàk j, mj;sk ;s;a; rih wju lrhs
fõ iy flaiSka iïñY%Kh jvd;a l,amj;sk iy fõ.j;a fm%daàk ñY%Khla we;s lrhs
w;HdjYH weuhsfkda wï, 09 lska iukaú; by< ÔjúoHd;aul w.hla we;s fm%daàk we,aìhï uÜgu  by< oeóu i|yd
i;a;j fïofhka f;dr fõ fudfkdawkaieÑhqf¾gâ fïo wï, iy fmd,swkaieÑshqf¾gâ fïo wï, iy uOHu m%udKfha g%hs.a,sirhsv j,ska wkQk jk w;ru ieÑhqf¾gâ fyj;a ix;Dma; fïo wï, j,g jvd wkaieÑhqf¾gâ fïo wï, m%udKh fo.=Khla muK wvx.= fõ
meKsrildrlhla f,i iqlarf,daia Ndú;h reêrfha iSks uÜgug fyda ldfndayhsfâ%g mßjD;a;Sh l%shdj,shg fyda bkaishq,Ska ksIamdokhg fyda ndOd we;s fkdlrhs
>k;ajh ^ñ,s ,Sgr 1 g lsf,dale,ß 1.04& k, wdOdrfhka jqjo ,nd Èh yel
wju Tiafud,e,sá w.h (440 mOsm/kg) Nhdkl m%;sM, ^mdpkh& j<lajhs

 

 

References :

1.Bellizzi V. Low Protein Diet or Nutritional Therapy in Chronic Kidney Disease?. Blood Purif 2013; 36:41-6.

2.Eustace JA, Coresh J, Kutchey C, Te PL, Gimenez LF, Scheel PJ, et.al. Randomized double-blind trial of oral essential amino acids for dialysis-associated hypoalbuminemia. [Internet]. [cited 2021 April 16th]. Available from: https://core.ac.uk/reader/82189560

3.Fouque D. Low Protein, Amino Acid and Ketoacid Diets to Slow the Progression of Chronic Kidney Disease and Improved Metabolic Control of Uremia. NutrManag Renal Dis. 2013; 209-31

4.Fouque D and Mitch WE, 2012. Dietary Approaches to Kidney Disease. In: Taal MW, Chertow GM, Mars PA, Skorecki K, Yu AS and Brenner BM. Editors. Brenner & Rector’s The Kidney. 9th ed. USA; Elsiver Saunders. 2170-204.

5.Garneata L; Mircescu G. Effect of Low Protein Diet Supplemented With Keto Acids on Progression of Chronic Kidney Disease. J Renal Nutr, 2013; 23: 210-3

6.Goldstein-Fuchs, D, LaPierre AM. 2014. Nutrition and Kidney Disease. In: Gilbert GJ, Weiner ME. Editors. National Kidney Foundation’s Primer on Kidney Diseases. Philadelphia; Elseiver Saunderz. P:467-74.

7.Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, et.al. KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. [Internet]. [cited 2021 April 16th]. Available from: https://www.ajkd.org/article/S0272-6386(20)30726-5/fulltext

8.NEPHRISOL[Product Information] Jakarta. Indonesia. PT Kalbe Farma Tbk; 2017

Preparation

fk*aßfid,a wdydr ,nd §fï wkqu; k, ud¾.hlska fyda idudkH f,i uqLdOdrfhka fyda ,nd .; yel

  • idudkH f,i uqLdOdrfhka fk*aßfid,a ,nd .ekSu    ñ,s,Sgr 250 l m%udKhla idod .ekSu i|yd WKq c,h ñ,s,Sgr 200 lg fk*aßfid,a .%Eï 61 l tla iefIa melÜgqjla ñY% lr Èh lr .kak fi,aishia wxYl 60 jvd jeä WIaK;ajhka hgf;a WKq lr .ekSu fyda msi .ekSfuka fuys wvx.= jk fm%daàk ix>gl úkdY ù hd yel wdydr fõ,a w;r;=r § fk*aßfid,a Ndú; l< yel
  • wkqu; k, ud¾.hlska ,nd §u     fï i|yd ffjoH Wmfoia wkq.ukh lrkak
  • fjk;a wdldr Tiafia ,nd .ekSfuka je<lsh hq;=h

Nutrition Fact

fuu fmdaIKSh mdkfhys ñ,s ,Sgr 1 g lsf,dale,ß 1.04 l w;HdjYh weuhsfkda wï, j¾. 09 l. w;HdjYh fkdjk weuhsfkd wï, j¾. 11, úgñka j¾. 11 l iy Lksc j¾. 7 l fmdaIKh wvx.= fõ’

fmdaIH mod¾: tallh tla jrlg ,efnk m%udKh ffoksl m%;sY;h
le,ß lsf,dale,ß 260
fïofhka ,efnk le,ß lsf,dale,ß 50
uq¿ fïoh .%Eï 6 9%
fudfkdawkaieÑhqf¾gâ fïo wï,h .%Eï 2.5
fmd,swkaieÑhqf¾gâ fïo wï,h .%Eï 1.5
g%dkaia fïo wï,h .%Eï 0
fldf,iagfrda,a ñ,s.%Eï 0
ix;Dma; fïoh .%Eï 2 10%
fm%daàk .%Eï 5 8%
uq¿ ldfndayhsfâ%g .%Eï 48 15%
uq¿ iSkS .%Eï 5  
iqlafrdia .%Eï 3
,elafgdia .%Eï 0
úgñka
úgñka A uhsfl%d.%Eï 75 15%
úgñka C ñ,s.%Eï 11 10%
úgñka D3 uhsfl%d.%Eï 0.83 6%
úgñka E ñ,s.%Eï 1.7 10%
úgñka B1 ñ,s.%Eï 0.23 15%
úgñka B2 ñ,s.%Eï 0.28 20%
úgñka B5 ñ,s.%Eï 1 20%
úgñka B6 ñ,s.%Eï 0.37 30%
úgñka B12 uhsfl%d.%Eï 0.33 15%
f*da,sla wï,h uhsfl%d.%Eï 67 15%
nfhdáka uhsfl%d.%Eï 12 40%
Lksc j¾.
fidaähï ñ,s.%Eï 87 6%
fmdagEishï ñ,s.%Eï 46 1%
le,aishï ñ,s.%Eï 120 10%
fmdiamria ñ,s.%Eï 79 10%
ue.akSaishï ñ,s.%Eï 20 6%
iskala ñ,s.%Eï 1.5 10%
fif,akshï uhsfl%d.%Eï 4.9 15%
w;HdjYh weuhsfkda wï,
,shqiSka .%Eï 0.6
whsfid¨iSka .%Eï 0.4
je,Ska .%Eï 0.5
á%mafgda*Eka .%Eï 0.1
f*ks,awe,kSka .%Eï 0.4
fu;sfhdkSka .%Eï 0.3
;s%hkSka .%Eï 0.3
,shsiSka .%Eï 0.4
ysiaáãka .%Eï 0.2
w;HjYhfkdjk weuhsfkda wï,      
weiamd¾ála wï,h .%Eï 0.2
.aÆgñla wï,h .%Eï 0.3
fißka .%Eï 0.1
.a,hsiska .%Eï 0.04
wd¾ðkska .%Eï 0.17
we,kSka .%Eï 0.1
;hsfrdiSka .%Eï 0.1
fm%da,Ska .%Eï 0.18
isiaàka .%Eï 0.04
fgdaÍka .%Eï 0.2
L – .aÆguhska .%Eï 0.2

Ingredients

fuda,afgdafvlaiaá%ka , t<j¿ f;,a ^lefkda,d. iQßhldka; mdï iy fmd,a f;,a& , iqlafrdia , weuhsfkda wï, , fõ fm%daàk , Lksc j¾. ^le,aishï ldnfkaÜ , fudfkdfidaähï fmdiafmaÜ fmdgEishï lf,darhsâ fidaähï laf,darhsâ , ue.akSishï Tlaihsâ iskala Tlaihsâ fidaähï fif,fkaÜ& , le,aishï flaisfkaÜ  lD;su jeks,d rildrl , iajNdúl wkkH;d lsß rildrl , úgñka ^ L fidaähï weiafldafíÜ , úgñka E , le,aishï fmkafgd;fkaÜ , úgñka A, msßfvdlaiska yhsfv%dlaf,darhsâ , úgñka D3 , ihfkdfldn,ñka , ;hñka yhsfv%dlaf,darhsâ , rhsfnda*,eúka , f*da,sla wï,h , nfhdaàka & tla wdydr fõ,lg iqlarf,dia rildrl .%Eï 22 la

Storage

újD; lrk ,o weiqreu isis,a úh<s msßisÿ ia:dkhl .nvd lrkak. weiqreu újD; l, Èk isg uila we;=,;§ Ndú; l< hq;=h.

Packaging & Flavor

tla weiqreul jeks,d rie;s fmdaIl msá .%Eï 183 l wvx.= fõ . .%Eï 61 ne.ska jQ ;=ka jrla Ndú; l, yels iefIa melÜ 3la wvx.= fõ .

FAQ

What is the content of NEPHRISOL?
NEPHRISOL is a special enteral nutrient for kidney dysfunction, has a composition of 63% carbohydrates, 7% protein and 30% fat and with mineral and vitamin contents that have been adjusted for pre-dialysis chronic kidney disease conditions. NEPHRISOL also has a low protein content, so it is in accordance with the recommended protein requirements for pre-dialysis kidney patients.
How many calories are produced from NEPHRISOL per serving?
NEPHRISOL contains calories of 260 Kcal / serving.
How many servings of NEPHRISOL can be consumed per day ?
If as a substitute food, NEPHRISOL can be given up to 6 times / day or adjusted to the needs and patient’s conditions. If as a complementary food can be given 2-3 times / day.
What is the calorie density of NEPHRISOL?
The calorie density of NEPHRISOL is 1.04 so that it can be given orally or tube feeding (the density does not exceed than 1.5).
What is the osmolality of NEPHRISOL?
NEPHRISOL osmolality is 354 mOsm / kg for vanilla variants
When can NEPHRISOL be used?
NEPHRISOL can be given to chronic kidney disease (pre-dialysis stage)
How is the presentation of NEPHRISOL?
Prepare 200 mL of warm boiled water with a temperature of <70 degrees Celsius then mix and stir until it is mixed homogeneously. Do not use hot water because it can damage the protein content.
How many times can NEPHRISOL be consumed a day?
NEPHRISOL if as a substitute food can be given up to 6 times / day or adjusted to the needs and conditions of the patient. If as a complementary meal can be given as much as 1-3 times / day.
Is it allowed if we put more than 4 spoons per serving to increase calorie?

Yes it’s allowed. Our product as complementary nutrition, that’s why the calorie is not high. It will be easier to adjust and patient can still eat their daily meals. Moreover we have amino acids premix which’s complying to the EAA: NEAA ratio following the guideline and is needed by patient, it is high biological value protein, an essential for every metabolic process, as main component to rebuild and maintain the balance of body functions, meanwhile other products don’t describe it.

If we put more than 4 spoons per serving, we need to add the water volume so we can maintain the density does not exceed than 1.5 kcal/mL

Can NEPHRISOL be combined with other enteral nutrients?
NEPHRISOL can be combined with other enteral nutrients if needed, but the dissolution process should be done separately.
What is the preparation for NGT patients?

The same with oral preparations depends on how many calorie patient needs. It can be accepted for the tube feeding size: 16 – 18 gauge and put each scoops gradually (while stirring and mix until dissolve to avoid the granules) and make sure that the density does not exceed than 1.5 kcal/mL

Can NEPHRISOL be given to patients with diabetes mellitus (DM)?
DM patients who are given NEPHRISOL to always monitor their blood sugar levels in order to stay controlled. Sometimes it is necessary to adjust the dose or adjust the type of diabetes medication so that the fulfillment of nutrition in DM patients is met.
What is the stability / method of storing NEPHRISOL before it is dissolved?
The unlocked NEPHRISOL lasts for 1 month as long as it stays in the aluminum bag. Store in a dry place with a temperature <25 degrees Celsius. It is not recommended to move NEPHRISOL into other places because it can interfere with its stability. If it is to be stored in a jar it should be together with the aluminum bag.
What is the stability / method of storing NEPHRISOL after dissolving?

NEPHRISOL which has been dissolved in 5 hours must be taken. If you have not finished drinking NEPHRISOL can be stored in the refrigerator, only afterwards it is not recommended to be heated (Microwave).

What is the source of carbohydrates used in Nephrisol?

Maltodextrin. Maltodextrin has the advantage of being easily absorbed so that it will optimize the formation of energy. Maltodextrin also dissolves easily, so the process of dissolving Nephrisol does not need to use hot water. Maltodextrin can help give volume (solid builder) by drawing water from dried products. Maltodextrin has a sweeter taste than sugar but has less sugar content, and serves to mask the fishy taste of fat and the bitter taste of protein content.

Why in the composition it has sucrose and sucralose together, what is their function?

The combination of those two sugars are to complement each other since we can't use too much sucrose to sweet the product, so we use sucralose to give the sweeter taste. However we also can't use sucralose as a single sweetener since: 1) Too much sucralose gives unpleasant aftertaste and give bad effect risk for glycemic and insulin response. 2) Sucralose itself doesn't have calorie, since this product aimed to meet the daily calorie needs for CKD patient, so sucrose addition may give worthy contribution to the calorie. 3) Sucralose is needed to mask the bitter amino acid taste.

What type of protein is used in Nephrisol?
Nephrisol contains a combination of whey protein (concentrate and isolate) and casein. Whey protein is fast digesting protein, so it is quickly used for protein synthesis. Casein is a slow digesting protein, which has the advantage of being able to last longer so that it can take over protein synthesis in the body when whey protein levels have started to fall. The combination of these has benefit in creating faster and longer protein synthesis.
Both of whey and casein contain amino acids, why in the composition stated: whey protein, casein, and also amino acids together?
To inform that beside the whey protein and casein, amino acid essential and non-essential amino acid is also clearly described, according with the guideline. Because we use premix AA, so we can describe the ratio EAA and NEAA, while other products don’t have it.
Why does Nephrisol have high biological value in protein?
Because it contains complete types of amino acids, which are needed for protein synthesis, namely essential amino acids and non-essential amino acids at the appropriate guideline ratio.
What is the source of fat used in Nephrisol?
Nephrisol is used vegetable fats: sunflower oil, canola oil and coconut oil which are rich in MUFA and PUFA, MCT, and also the content of unsaturated fatty acids higher (twice higher) than saturated fatty acids
What kind of sweetener that is used in Nephrisol?
Sucralose. Sucralose is non calorie sweetener, it is not metabolized in the body into energy and does not affect blood sugar levels, carbohydrate metabolism or insulin production
Why should Nephrisol not be dissolved in hot water?
When the protein is heated, the protein becomes clotted because the peptide bonds are destroyed by heat, because the middle group contains a positive charge and the carbonyl contains a negative charge whose kinetic increases when hot. After clotting, the peptidase enzyme can no longer work on the protein. The more peptide chains and the longer the structure, the greater the chance that the protein will be damaged by heat.
Is it possible to be given to diabetes patients?
Nephrisol can be given to diabetes patients whose glucose levels have been controlled. The calorie concentration is not categorized as high, which is 1 kcal/mL. After Nephrisol is given, as it is with nutritional therapy in general, glucose levels should be monitored accordingly.
What is the role of Nephrisol as a food supplement or substitute?
Both. As a food supplement Nephrisol can be consumed to meet the adequacy of protein and calories that are not met from the daily diet, as a substitute food Nephrisol can be consumed if the patient is completely unable to eat.