Hepatosol Sri Lanka – Kalbe International

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ksoka.; wlaud frda. jeks frda.hka i|ydu úfYaIfhkau ilia lrk ,o fmdaIK w;sf¾lhls “fymgfida,a“ .

—fymgfida,a˜ ys wvx.= fmdaIH mod¾: (

by< Yla;sckl iy fm%daàk fldgia
uOHu m%udKfha g%hs.a,hsirhsv
whsfid¨iSka, ,shqiSka iy je,Ska hk YdLd odu weuhsfkda wï, j¾.
úgñka iy Lksc mod¾:hka

Feature Benefit

úfYaI ,laIKh	m%;s,dN
by< Yla;sh ^tla jrlg lsf,da le,ß 380&	wlaudj m%;sckkh lsÍug iy fmdaIK mod¾: kej; msysgqùu iy mj;ajd f.k hEu
by< fm%daàk w.hka ^tla jrlg .%Eï 12&	wlaudfjys ffi, m%;sckkh lsÍug iy khsg%cka uÜgu ksisf,i mj;ajd .ekSu. flfia kuq;a fuu m%udKh rla;md; fldaud ;;ajhka we;s lsÍug ;rï m%udKj;a fkdfõ
uOHu m%udKfha g%hs.a,hsirhsv ^tla jrlg .%Eï 14& whsfid¨iSka ,shqiSka iy je,Ska hk YdLd odu weuhsfkda wï, j¾.	wlaudjg fïofhka úh yels ydks j,ska wdrlaId lrk w;r;=ru u;aøjH Ndú;fhka yg .;a ;=jd, iqj lsÍu wlaudfjys l%shdldrS;ajh j¾Okh lsÍu iy frday,a urK wkqmd;h wju lsÍu
Úgñka A,B,C,D, iy E	wlaud fldaIaG kej; ilia lsÍu iy úfYaIfhkau wdydr wreÑfhka fmf<kakd jQ frda.Skaf.a mgl kej; w¿;ajeähd lsÍu
Lksc ^le,aishï, hlv iy iskala&	iskala – m%;sTlaisldrlhla f,i l%shdlrhs ^.aÆg;sfhdka m%udKh by< ouhs& hlv – wekSñhd j<lhs le,aishï – wiaÓ laIh ùu j<lhs
my< Tiafud,e,sá w.h ^lsf,da.%Eï 1g ñ,sTiafud,a 415&	wdudY wdka;rdhsl le<öï we;s jSfï wjOdku wju lsÍu iy k, wdOdrfhka jqjo ,nd Èh yel
>k;ajh ^ñ,s ,Sgr 1 g lsf,dale,ß 1.05&	k, wdOdrfhka jqjo ,nd Èh yel

References :

1.Fukui A, Kawabe N, Hashimoto S, Murao M, Nakano T, Shimazaki H, et al. Additional BCAA-enriched nutrient mixture improves the nutritional condition in cirrhotic patients with hypoalbuminemia despite treatment with regular BCAA granules: A pilot study. Turk J Gastroenterol 2015; 26: 328-35

2.Maki H, Yamanaka-Okumura H, Katayama T, Ozawa Y, Hosoda A, Kurata N, et al. Late evening snacks with branched-chain amino acids improve the Fischer ratio with patients liver cirrhosis at fasting in the next morning. [Internet]. [cited 2020 May 5th ]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30904214

3.HEPATOSOL[Product Information] Jakarta. Indonesia. PT Kalbe Farma Tbk; 2020

4.Park JG, Tak WY, Park SY, Kweon YO, Jang SY, Lee YR, et al. Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease. Medicine 2017:96-24.

5.Plauth M, Bernal W, Dasarathy S, Merli M, Plank LD, Schutz T, et al., ESPEN guideline on clinical nutrition in liver disease. [Internet]. [cited 2020 May 5th]. Available from: https://www.espen.org/files/ESPEN-Guidelines/ESPEN-guideline-liver-disease-2019.pdf

6.Sanchez AJ, Aranda-Michel J. Nutrition for the liver transplant patient. Liver Transpl. 2006 Sep;12(9):1310-6

Preparation

fymgfid,a wdydr ,nd §fï wkqu; k, ud¾.hlska fyda idudkH wldrfhka fyda ,nd .; yel.

idudkH wdldrfhka fymgfida,a ,nd .ekSu – ñ,s,Sgr 363 l m%udKhla idod .ekSu i|yd WKq c,h ñ,s,Sgr 300 lg fymgfida,a .%Eï 80 l tla iefIa melÜgqjla ñY% lr Èh lr .kak. fi,aishia wxYl 60 jvd jeä WIaK;ajhka hgf;a WKq lr .eku fyda msi .ekSfuka fuys wvx.= jk fm%daàk ix>gl úkdY ù hd yel.
wkqu; k, ud¾.hlska ,nd §u – fï i|yd ffjoH Wmfoia wkq.ukh lrkak
fjk;a wdldr Tiafia ,nd .ekSfuka je<lsh hq;=h

Nutrition Fact

fuu fmdaIKSh mdkfhys by< fm%daàk, ñ,s ,Sgr 1 g lsf,dale,ß 1.05 whsfid¨iSka, ,shqiSka iy je,Ska hk weófkda wï, j¾., uOHu m%udKfha g%hs.a,hsirhsv, úgñka j¾. 12 lska iy Lksc j¾. 7 l fmdaIKh wvx.= fõ.

fmdaIH mod¾:	tallh	tla jrlg ,efnk m%udKh	ffoksl m%;sY;h
le,ß	lsf,dale,ß	380
fïofhka ,efnk le,ß	lsf,dale,ß	140
uq¿ fïoh	.%Eï	15	23%
fudfkdawkaieÑhqf¾gâ fïo wï,h	.%Eï	0
fmd,swkaieÑhqf¾gâ fïo wï,h	.%Eï	0
g%dkaia fïo wï,h	.%Eï	0
fldf,iagfrda,a	ñ,s.%Eï	2	1%
ix;Dma; fïoh	.%Eï	15	76%
uOHu m%udKfha g%hs.a,hsirhsv	.%Eï	14
fm%daàk	.%Eï	12	19%
uq¿ ldfndayhsfâ%g	.%Eï	49	15%
wdydruh ;ka;=	.%Eï	2	7%
uq¿ iSkS	.%Eï	23	15%
,elafgdia iqlafrdia	.%Eï .%Eï	0 17
úgñka
úgñka A	uhsfl%d.%Eï	93	15%
úgñka B₁$;shñka	ñ,s.%Eï	0.18	15%
úgñka B₂$rhsfnd*a,eúka	ñ,s.%Eï	0.2	15%
úgñka B₃$ khiska	ñ,s.%Eï	1.8	10%
Úgñka $ mekafgdf;ksla wï,h	ñ,s.%Eï	0.77	15%
úgñka B₆$msßfvdlaiska	ñ,s.%Eï	0.14	10%
f*da,sla wï,h	uhsfl%d.%Eï	58	15%
úgñka B₁₂$fldn,ñka	uhsfl%d.%Eï	0.32	15%
úgñka C	ñ,s.%Eï	11	10%
úgñka D₃	uhsfl%d.%Eï	2.3	15%
úgñka E	ñ,s.%Eï	2.2	15%
nfhdáka	uhsfl%d.%Eï	3.7	10%
Lksc j¾.
fidaähï	ñ,s.%Eï	170	11%
fmdagEishï	ñ,s.%Eï	60	1%
le,aishï	ñ,s.%Eï	150	15%
fmdiamria	ñ,s.%Eï	82	10%
hlv	ñ,s.%Eï	3.4	15%
whãka	uhsfl%d.%Eï	18	10%
iskala	ñ,s.%Eï	1.3	10%
YdLd odu weuhsfkda wï,
,shqiSka	.%Eï	1.22
whsfid¨iSka	.%Eï	0.80
je,Ska	.%Eï	0.64

Ingredients

fuda,afgdafvlaiaá%ka, uOHu m%udKfha g%hs.a,hsirhsv msá, iqlafrdaia, tal,s; fõ fm%daàk, idkaø fõ fm%daàk, bkshq,ska, YdLd odu weuhsfkda wï, ^ whsfid¨iSka, ,shqiSka, je,Ska &, le,aishï ldnfkaÜ, fidaähï laf,darhsâ, fidaähï fudfkdfmdiafmaÜ, lD;su jeks,d rildrl, t<j¿ f;,a l=vq ^iQ¾hldka; iy /maiSâ f;,a ñY%Kh&, iajNdúl wkkH;d lsß rildrl, úgñka iy Lksc ñY%Kh ^fidaähï weifldfíÜ, f*ßl mhsfrdafmdiafmaÜ, úgñka E, iskala Tlaihsâ”&, ksfldákquhsâ, úgñka ta me,añfÜÜ, úgñka D_3,le,aishï fmkafgd;fkaÜ, ihfkdfldn,uhska, rhsfnda*,eúka, ;hñka yhsfv%dlaf,darhsâ, msßfvdlaiska yhsfv%dlaf,darhsâ, f*da,sla wï,h, fmdgEishï whvhsâ”nfhdaàka&

Storage

újD; lrk ,o weiqreu isis,a úh<s msßisÿ ia:dkhl .nvd lrkak. weiqreu újD; l, Èk isg uila we;=,;§ Ndú; l< hq;=h.

Packaging & Flavor

tla weiqreul jeks,d rie;s fmdaIl msá .%Eï 240 l wvx.= fõ. .%Eï 80 ne.ska jQ ;=ka jrla Ndú; l, yels iefIa melÜ 3la wvx.= fõ.

FAQ

What is the content of HEPATOSOL?

HEPATOSOL is an enteral nutrition specifically for liver function disorders, has a composition of 62% carbohydrate, 13% protein and 35% fat and is equipped with specific nutrients such as BCAA to increase the Fischer ratio and the process of restoring muscle protein, and MCT which is a type of fat that is easier to digest and metabolized and easy to use as an alternative energy source.

How many calories/serving of HEPATOSOL ?

HEPATOSOL contains 380 kcal/serving

What is the calorie density of HEPATOSOL?

The calorie density of HEPATOSOL is 1.04 so it can be given by orally or stube feeding.

What is the osmolality of HEPATOSOL?

The osmolality of HEPATOSOL is 415 mOsm/kg

Can HEPATOSOL be concentrated / diluted?

HEPATOSOL can be concentrated / diluted according to the patient's condition and tolerance. In concentrated HEPATOSOL, please pay attention to it’s density, especially when given through a feeding tube, so that HEPATOSOL can enter the feeding tube smoothly.

In what clinical condition can HEPATOSOL be used?

HEPATOSOL can be given to patients with chronic liver disease who suffer from malnutrition / anorexia so that are not able to maintain adequate oral intake from daily meal

How do we prepare HEPATOSOL?

Mix 1 sachet (80 g) of HEPATOSOL into a 300 mL of warm boiled water at a temperature of <70 degrees Celsius, stir and mix until dissolve. It’s not advisable to cook / boil in high temperature, above 700C, as it may denature protein content of HEPATOSOL

How many servings of HEPATOSOL can be consumed per day ?

If as a substitute food, HEPATOSOL can be given up to 6 times / day or adjusted to the needs and patient’s conditions. If as a complementary food can be given 1-3 times / day.

Can HEPATOSOL be combined with other enteral nutrients?

HEPATOSOL can be combined with other enteral nutrients if needed, but the dissolution process should be separately.

Can HEPATOSOL be given to diabetes mellitus (DM) patients?

There is no study of HEPATOSOL in diabetic patients, but considering there are carbohydrates derived from maltodextrin so that it can still affect the blood glucose levels of diabetic patients. DM patients who are given HEPATOSOL have to monitor their blood sugar levels in order to stay controlled. Sometimes, it requires to adjust the dose or the type of diabetes medication so that the fulfillment of nutrition in DM patients is fulfilled.

How is the stability / storage method of HEPATOSOL before it is dissolved?

The stability for HEPATOSOL that has been opened is about 1 month as long as it stays in the aluminum foil bag. Storage condition: in a dry place with a temperature < 25 degrees Celsius. It is not recommended to move HEPATOSOL into another container because it can interfere with its stability. If it is to be stored in a jar it should be together with the aluminum bag.

What is the stability / storage method of HEPATOSOL after it is dissolved?

HEPATOSOL which has dissolved within 5 hours must be consumed. If you have not taken it, HEPATOSOL can be stored in the refrigerator, only after that it is not recommended to be heated (Microwave).

What is the packaging form of HEPATOSOL?

Packaging form of HEPATOSOL is a single sachet (80 g / sachet) which is there are 3 sachets in a box.

The recommended dosage of HEPATOSOL is 3 servings/day, how to use HEPATOSOL as late evening snack ?

Hepatosol should be given 3 times a day, where out of 3 times, once at night, because from clinical studies it was found that late evening snacks with BCAA can improve the balance of albumin and nitrogen in patients. This happens because a patient with fasting cirrhosis for 1 day is the same as a normal fasting person for 3 days. When cirrhosis patients sleep at night for 8 hours is same with fast 24 hours in normal people, so it is advisable to be given a night snack to provide a reserve of nutrition during the night's rest.

Is there a risk of diarrhoea?

One of the risks of enteral nutrition is gastrointestinal disorders including nausea, vomiting and diarrhea. However, these side effects are very rare. Gastrointestinal side effects are generally found due to large doses.

Can HEPATOSOL be combined with parenteral nutrition?

Yes it can, Hepatosol can be consumed as complementary food, replacement food aor as a combination with parenteral nutrition.

Why is it recommended to give 3 times a day(morning, evening and 1 time at night)?

We recommend from 3 times the administration, there is 1 time giving hepatosol at night late evening snack) because there are studies showed that giving a high BCAA as late evening snack can provide better albumin levels, more positive nitrogen balance, and a better fischer ratio.

Can HEPATOSOL be given to children?

There is no study of HEPATOSOL in children. However, remembering is an amino acid (protein) so that it is not harmful, it only needs to adjust the dose and pay attention to the calorie needs of children.

Can HEPATOSOL be given to pregnant women?

There is no study of HEPATOSOL in pregnant women but Because of HEPATOSOL contains nutrients that are normally obtained every-day and are not contraindicated for pregnant women, HEPATOSOL can be given; if, needed.

Can hepatosol be given to patients with cholestasis because it contains MCT?

Hepatosol can be given to all liver function disorders including cholestasis because the fat comes from MCT so that it does not make the liver work harder. However, close monitoring of liver function and markers of cholestasis must be carried out.

Why is the fat content in Hepatosol high?

High fat in Hepatosol aims to increase calorie content. Types of fat used in HEPATOSOL is MCT (Medium Chain Triglycerides), which is the type of fat recommended for liver patients.

Brands Info

Feature Benefit

Preparation

Nutrition Fact

Ingredients

Storage

Packaging & Flavor

FAQ

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